| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a1 |
TP53_mut |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
554 |
292 |
2.08, 1.39 |
2.52 |
4.06 |
1.54 |
1.3 * |
1.1 * |
1.6 * |
1.06e-54 |
1.98e-43 |
3.29e-02 |
1.7e-47 |
a63 |
loss_cnaPANCAN313 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
70 |
776 |
2.08, 1.39 |
3.49 |
3.98 |
0.492 |
0.36 |
0.36 |
0.5 |
2.23e-06 |
3.67e-32 |
6.23e-02 |
0.58 |
a66 |
loss_cnaPANCAN312 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
75 |
771 |
2.08, 1.39 |
3.48 |
3.95 |
0.466 |
0.35 |
0.34 |
0.43 |
2.41e-06 |
3.73e-32 |
6.24e-02 |
0.6 |
a67 |
loss_cnaPANCAN307_(CHD3,GPS2,TP53) |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
99 |
747 |
2.08, 1.39 |
3.48 |
3.88 |
0.4 |
0.3 |
0.29 |
0.37 |
2.62e-06 |
3.79e-32 |
6.24e-02 |
0.64 |
a83 |
loss_cnaPANCAN311 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
78 |
768 |
2.08, 1.39 |
3.49 |
3.92 |
0.433 |
0.32 |
0.31 |
0.4 |
5.02e-06 |
4.32e-32 |
6.26e-02 |
1 |
a93 |
CTNNB1_mut |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
17 |
829 |
2.08, 1.39 |
3.55 |
2.33 |
-1.22 |
0.9 . |
0.9 . |
1 . |
8.07e-06 |
4.75e-32 |
6.27e-02 |
1.4 |
a105 |
loss_cnaPANCAN308 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
81 |
765 |
2.08, 1.39 |
3.49 |
3.83 |
0.337 |
0.25 |
0.24 |
0.3 |
1.63e-05 |
5.46e-32 |
6.29e-02 |
2.6 |
a126 |
loss_cnaPANCAN305 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
69 |
777 |
2.08, 1.39 |
3.5 |
3.85 |
0.347 |
0.26 |
0.25 |
0.31 |
2.22e-05 |
5.81e-32 |
6.3e-02 |
2.9 |
a154 |
loss_cnaPANCAN304 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
68 |
778 |
2.08, 1.39 |
3.5 |
3.83 |
0.328 |
0.24 |
0.24 |
0.29 |
4.27e-05 |
6.61e-32 |
6.32e-02 |
4.6 |
a168 |
loss_cnaPANCAN309 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
77 |
769 |
2.08, 1.39 |
3.5 |
3.81 |
0.312 |
0.23 |
0.23 |
0.28 |
5.35e-05 |
6.91e-32 |
6.33e-02 |
5.3 |
a170 |
ANK3_mut |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
20 |
826 |
2.08, 1.39 |
3.51 |
4.33 |
0.828 |
0.61 . |
0.61 . |
0.89 . |
5.51e-05 |
6.95e-32 |
6.33e-02 |
5.3 |
a207 |
loss_cnaPANCAN310_(MAP2K4) |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
89 |
757 |
2.08, 1.39 |
3.49 |
3.87 |
0.381 |
0.28 |
0.28 |
0.34 |
9.18e-05 |
7.69e-32 |
6.35e-02 |
7.3 |
a235 |
loss_cnaPANCAN306 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
70 |
776 |
2.08, 1.39 |
3.5 |
3.8 |
0.296 |
0.22 |
0.22 |
0.24 |
1.26e-04 |
8.18e-32 |
6.36e-02 |
8.8 |
a255 |
KRAS_mut |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
108 |
738 |
2.08, 1.39 |
3.53 |
3.53 |
0.00118 |
0.00087 |
0.00087 |
0.00083 |
1.59e-04 |
8.56e-32 |
6.36e-02 |
10 |
a286 |
loss_cnaPANCAN314 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
28 |
818 |
2.08, 1.39 |
3.5 |
4.26 |
0.759 |
0.56 . |
0.56 . |
0.76 . |
2.12e-04 |
9.05e-32 |
6.37e-02 |
12 |
