ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:41 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: loss_cnaPANCAN308


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN308 deleted (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 98


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a105	loss_cnaPANCAN308	1047	1	1	Nutlin-3a	MDM2	81	765	2.08, 1.39	3.49	3.83	0.337	0.25	0.24	0.3	1.63e-05	5.46e-32	6.29e-02	2.6
a244	loss_cnaPANCAN308	1378	1	1	Bleomycin (50 uM)	DNA damage	91	841	3.91	2.23	3.22	0.991	0.48	0.47	0.56 .	1.46e-04	5.83e-31	3.33e-04	9.9
a364	loss_cnaPANCAN308	110	1	1	Roscovitine	CDKs	47	350	2.77	3.87	4.32	0.442	0.46	0.46	0.42	3.67e-04	2.1e-04	8.98e-01	17
a480	loss_cnaPANCAN308	1175	1	1	AG-014699	PARP1, PARP2	87	831	1.61	3.39	3.71	0.314	0.32	0.31	0.39	6.66e-04	9.78e-15	1.24e-01	23

All-tests volcano plot