ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:17 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: TP53_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in TP53

Number of cell lines positive for this feature: 654


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a1	TP53_mut	1047	1	1	Nutlin-3a	MDM2	554	292	2.08, 1.39	2.52	4.06	1.54	1.3 *	1.1 *	1.6 *	1.06e-54	1.98e-43	3.29e-02	1.7e-47
a50	TP53_mut	1242	1	1	(5Z)-7-Oxozeaenol	MAP3K7 (TAK1)	602	311	2.3	0.32	1.09	0.774	0.56 .	0.51 .	0.59 .	4.19e-07	6.57e-46	6.09e-01	0.14
a112	TP53_mut	1378	1	1	Bleomycin (50 uM)	DNA damage	616	316	3.91	1.88	2.55	0.671	0.33	0.34	0.32	1.74e-05	4e-31	3.23e-04	2.6
a121	TP53_mut	1373	1	1	Dabrafenib	BRAF	577	293	2.3	2.63	3.59	0.957	0.5 .	0.4	0.6 .	2.05e-05	6.24e-67	1.19e-01	2.8

All-tests volcano plot