ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:51 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual Feature analysis: loss_cnaPANCAN304
Feature details and cell panel numbers
Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN304 deleted (see genomic region decoding file for further infos on this region)
Number of cell lines positive for this feature: 83
Statistically significant associations identified = 5
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a154 |
loss_cnaPANCAN304 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
68 |
778 |
2.08, 1.39 |
3.5 |
3.83 |
0.328 |
0.24 |
0.24 |
0.29 |
4.27e-05 |
6.61e-32 |
6.32e-02 |
4.6 |
a174 |
loss_cnaPANCAN304 |
110 |
1 |
1 |
Roscovitine |
CDKs |
43 |
354 |
2.77 |
3.87 |
4.36 |
0.485 |
0.5 . |
0.5 . |
0.51 . |
6.01e-05 |
1.8e-04 |
8.98e-01 |
5.6 |
a230 |
loss_cnaPANCAN304 |
300 |
1 |
1 |
CX-5461 |
RNA Pol I |
73 |
844 |
2.33 |
2.97 |
3.27 |
0.301 |
0.15 |
0.15 |
0.17 |
1.23e-04 |
6.82e-45 |
2.24e-01 |
8.8 |
a309 |
loss_cnaPANCAN304 |
179 |
1 |
1 |
5-Fluorouracil |
DNA antimetabolite |
73 |
840 |
3.47 |
3.54 |
3.78 |
0.233 |
0.13 |
0.13 |
0.13 |
2.71e-04 |
2.17e-45 |
2.32e-01 |
14 |
a324 |
loss_cnaPANCAN304 |
1378 |
1 |
1 |
Bleomycin (50 uM) |
DNA damage |
76 |
856 |
3.91 |
2.24 |
3.33 |
1.09 |
0.53 . |
0.53 . |
0.63 . |
2.94e-04 |
6.59e-31 |
3.36e-04 |
15 |
All-tests volcano plot
