ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1012


Drug details and screening numbers

Drug Name: Vorinostat
Drug ID: 1012
Synonyms: SAHA
Brand name: Zolinza
Target: HDAC inhibitor Class I, IIa, IIb, IV

Number of cell lines screened: 851
Screening concentration range(s): 0.0390625 to 10 uM


Statistically significant associations identified = 6

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a103	loss_cnaPANCAN167	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	19	829	2.3	0.977	1.85	0.872	0.75 .	0.76 .	0.45	1.44e-05	2.19e-46	3.94e-01	2.3
a157	loss_cnaPANCAN168	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	22	826	2.3	0.978	1.71	0.727	0.62 .	0.63 .	0.38	4.59e-05	2.97e-46	3.95e-01	4.8
a158	gain_cnaPANCAN280_(ARID4B,FH)	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	52	796	2.3	0.952	1.69	0.738	0.63 .	0.65 .	0.5	4.91e-05	3.02e-46	3.95e-01	5.1
a337	loss_cnaPANCAN357_(ACVR2A)	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	21	827	2.3	0.977	1.77	0.79	0.68 .	0.68 .	0.6 .	3.12e-04	4.88e-46	3.96e-01	15
a435	gain_cnaPANCAN213_(MCM3)	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	47	801	2.3	0.953	1.75	0.796	0.68 .	0.7 .	0.53 .	5.34e-04	5.59e-46	3.96e-01	20
a507	loss_cnaPANCAN250_(SRGAP3)	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	143	705	2.3	0.934	1.31	0.374	0.32	0.33	0.28	7.45e-04	6.09e-46	3.96e-01	24

All-tests volcano plot