ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:28 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: gain_cnaPANCAN280_(ARID4B,FH)


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN280_(ARID4B,FH) amplified (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 59


Statistically significant associations identified = 12

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a45	gain_cnaPANCAN280_(ARID4B,FH)	1003	1	1	Camptothecin	TOP1	52	794	-2.3	-4.14	-2.53	1.61	0.92 .	0.94 .	0.76 .	1.45e-07	9.27e-24	1.02e-01	0.053
a158	gain_cnaPANCAN280_(ARID4B,FH)	1012	1	1	Vorinostat	HDAC inhibitor Class I, IIa, IIb, IV	52	796	2.3	0.952	1.69	0.738	0.63 .	0.65 .	0.5	4.91e-05	3.02e-46	3.95e-01	5.1
a180	gain_cnaPANCAN280_(ARID4B,FH)	1057	1	1	NVP-BEZ235	PI3K (Class 1) and MTORC1/2	50	789	-1.386, 0.693	-2.49	-1.82	0.667	0.55 .	0.56 .	0.45	6.33e-05	8.18e-14	2.78e-02	5.8
a183	gain_cnaPANCAN280_(ARID4B,FH)	1015	1	1	CI-1040	MAP2K1 (MEK1), MAP2K2 (MEK2)	50	786	2.3	2.18	3.21	1.03	0.7 .	0.71 .	0.63 .	6.42e-05	2.76e-38	2.65e-02	5.8
a191	gain_cnaPANCAN280_(ARID4B,FH)	1009	1	1	ATRA	Retinoic acid and retinoid X receptor agonist	51	786	2.3	3.85	4.63	0.776	0.6 .	0.59 .	0.92 .	7.31e-05	4.12e-31	2.1e-01	6.3
a208	gain_cnaPANCAN280_(ARID4B,FH)	1007	1	1	Docetaxel	Microtubules	52	795	-4.38	-4.94	-4.25	0.686	0.46	0.46	0.42	9.19e-05	3.1e-31	2.57e-01	7.3
a231	gain_cnaPANCAN280_(ARID4B,FH)	1004	1	1	Vinblastine	Microtubules	52	795	-2.3	-4.1	-3.26	0.837	0.56 .	0.57 .	0.49	1.23e-04	7.06e-17	2.79e-02	8.8
a257	gain_cnaPANCAN280_(ARID4B,FH)	1050	1	1	ZM-447439	AURKB	47	749	1.386, 0.693	2.18	2.97	0.796	0.64 .	0.64 .	0.54 .	1.61e-04	2.86e-12	2.74e-02	10
a366	gain_cnaPANCAN280_(ARID4B,FH)	1011	1	1	ABT-263	BCL2, BCL2L1, BCL2L2	51	795	0.693	1.17	2.25	1.08	0.57 .	0.57 .	0.67 .	3.71e-04	1.3e-55	8.54e-03	17
a391	gain_cnaPANCAN280_(ARID4B,FH)	1054	1	1	PD-0332991	CDK4, CDK6	50	773	1.386, 0.693	1.71	2.68	0.963	0.6 .	0.61 .	0.54 .	4.34e-04	3.44e-27	1.9e-02	18
a459	gain_cnaPANCAN280_(ARID4B,FH)	1494	1	1	SN-38	TOP1	55	872	-3	-4.28	-3.29	0.993	0.6 .	0.6 .	0.52 .	5.97e-04	2.86e-20	4.72e-03	21
a498	gain_cnaPANCAN280_(ARID4B,FH)	1020	1	1	Lenalidomide	TNFA	52	796	1.61	3.83	4.32	0.489	0.62 .	0.61 .	0.71 .	7.07e-04	7.96e-35	1.43e-01	23

All-tests volcano plot