ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:10 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1057


Drug details and screening numbers

Drug Name: NVP-BEZ235
Drug ID: 1057
Synonyms: BEZ235
Brand name:
Target: PI3K (Class 1) and MTORC1/2

Number of cell lines screened: 842
Screening concentration range(s): 0.0009765625 to 0.25 uM and 0.0078125 to 2 uM


Statistically significant associations identified = 5

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a180	gain_cnaPANCAN280_(ARID4B,FH)	1057	1	1	NVP-BEZ235	PI3K (Class 1) and MTORC1/2	50	789	-1.386, 0.693	-2.49	-1.82	0.667	0.55 .	0.56 .	0.45	6.33e-05	8.18e-14	2.78e-02	5.8
a334	gain_cnaPANCAN411_(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6)	1057	1	1	NVP-BEZ235	PI3K (Class 1) and MTORC1/2	24	815	-1.386, 0.693	-2.47	-1.53	0.942	0.78 .	0.79 .	0.57 .	3.02e-04	9.61e-14	2.81e-02	15
a336	loss_cnaPANCAN93	1057	1	1	NVP-BEZ235	PI3K (Class 1) and MTORC1/2	87	752	-1.386, 0.693	-2.51	-1.91	0.605	0.5 .	0.51 .	0.47	3.09e-04	9.64e-14	2.81e-02	15
a369	loss_cnaPANCAN94	1057	1	1	NVP-BEZ235	PI3K (Class 1) and MTORC1/2	89	750	-1.386, 0.693	-2.51	-1.92	0.593	0.49	0.5	0.47	3.77e-04	9.83e-14	2.81e-02	17
a390	loss_cnaPANCAN97	1057	1	1	NVP-BEZ235	PI3K (Class 1) and MTORC1/2	92	747	-1.386, 0.693	-2.51	-1.93	0.581	0.48	0.48	0.48	4.33e-04	9.97e-14	2.82e-02	18

All-tests volcano plot