ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:12 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1494


Drug details and screening numbers

Drug Name: SN-38
Drug ID: 1494
Synonyms: 7-ETHYL-10-HYDROXY-CAMPTOTHECIN
Brand name:
Target: TOP1

Number of cell lines screened: 930
Screening concentration range(s): 0.0001953125 to 0.05 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a363	gain_cnaPANCAN411_(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6)	1494	1	1	SN-38	TOP1	26	901	-3	-4.26	-3.02	1.24	0.74 .	0.75 .	0.58 .	3.66e-04	2.69e-20	4.7e-03	17
a432	EWSR1-FLI1_mut	1494	1	1	SN-38	TOP1	18	909	-3	-4.19	-6.02	-1.83	1.1 *	1.1 *	0.96 .	5.29e-04	2.82e-20	4.71e-03	20
a459	gain_cnaPANCAN280_(ARID4B,FH)	1494	1	1	SN-38	TOP1	55	872	-3	-4.28	-3.29	0.993	0.6 .	0.6 .	0.52 .	5.97e-04	2.86e-20	4.72e-03	21

All-tests volcano plot