ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1015


Drug details and screening numbers

Drug Name: CI-1040
Drug ID: 1015
Synonyms: PD-18435,PD-184352
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 839
Screening concentration range(s): 0.0390625 to 10 uM


Statistically significant associations identified = 5
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a65
KRAS_mut
1015
1
1
CI-1040
MAP2K1 (MEK1), MAP2K2 (MEK2)
109
727
2.3
2.35
1.56
-0.783
0.54 .
0.53 .
0.61 .
2.4e-06
1.29e-38
2.59e-02
0.6
a95
BRAF_mut
1015
1
1
CI-1040
MAP2K1 (MEK1), MAP2K2 (MEK2)
70
766
2.3
2.38
0.711
-1.67
1.2 *
1.2 *
1.1 *
8.68e-06
1.74e-38
2.61e-02
1.5
a97
NRAS_mut
1015
1
1
CI-1040
MAP2K1 (MEK1), MAP2K2 (MEK2)
56
780
2.3
2.33
1.09
-1.24
0.85 .
0.86 .
0.8 .
8.77e-06
1.75e-38
2.61e-02
1.5
a183
gain_cnaPANCAN280_(ARID4B,FH)
1015
1
1
CI-1040
MAP2K1 (MEK1), MAP2K2 (MEK2)
50
786
2.3
2.18
3.21
1.03
0.7 .
0.71 .
0.63 .
6.42e-05
2.76e-38
2.65e-02
5.8
a285
HGF_mut
1015
1
1
CI-1040
MAP2K1 (MEK1), MAP2K2 (MEK2)
4
832
2.3
2.23
4.29
2.06
1.4 *
1.4 *
1.8 *
2.08e-04
3.61e-38
2.67e-02
12


All-tests volcano plot