| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a15 |
NRAS_mut |
1060 |
1 |
1 |
PD-0325901 |
MAP2K1 (MEK1), MAP2K2 (MEK2) |
54 |
784 |
-1.386, 0.693 |
-0.994 |
-2.57 |
-1.58 |
0.9 . |
0.9 . |
0.86 . |
1.51e-10 |
2.24e-47 |
3.05e-02 |
0.00017 |
a20 |
NRAS_mut |
1014 |
1 |
1 |
RDEA119 |
MAP2K1 (MEK1), MAP2K2 (MEK2) |
54 |
783 |
1.61 |
1.64 |
0.0136 |
-1.62 |
0.92 . |
0.92 . |
0.84 . |
4.75e-10 |
1.37e-52 |
9.97e-02 |
0.00039 |
a52 |
NRAS_mut |
1372 |
1 |
1 |
Trametinib |
MAP2K1 (MEK1), MAP2K2 (MEK2) |
55 |
838 |
0 |
-0.92 |
-2.77 |
-1.85 |
0.75 . |
0.76 . |
0.65 . |
5.36e-07 |
5.91e-63 |
2.16e-01 |
0.17 |
a54 |
NRAS_mut |
1498 |
1 |
1 |
AZD6244 |
MAP2K1 (MEK1), MAP2K2 (MEK2) |
57 |
861 |
1.39 |
1.73 |
0.364 |
-1.37 |
0.8 . |
0.8 . |
0.73 . |
8.74e-07 |
1.08e-54 |
6.11e-02 |
0.27 |
a90 |
NRAS_mut |
261 |
1 |
1 |
TL-1-85 |
MAP3K7 (TAK1) |
58 |
861 |
2.33 |
3.18 |
3.03 |
-0.153 |
0.093 |
0.092 |
0.11 |
7.33e-06 |
2.09e-75 |
5.72e-01 |
1.3 |
a94 |
NRAS_mut |
1526 |
1 |
1 |
RDEA119 (rescreen) |
MAP2K1 (MEK1), MAP2K2 (MEK2) |
53 |
822 |
1.61 |
1.78 |
0.457 |
-1.32 |
0.8 . |
0.8 . |
0.76 . |
8.08e-06 |
3.56e-62 |
1.68e-01 |
1.4 |
a97 |
NRAS_mut |
1015 |
1 |
1 |
CI-1040 |
MAP2K1 (MEK1), MAP2K2 (MEK2) |
56 |
780 |
2.3 |
2.33 |
1.09 |
-1.24 |
0.85 . |
0.86 . |
0.8 . |
8.77e-06 |
1.75e-38 |
2.61e-02 |
1.5 |
a98 |
NRAS_mut |
260 |
1 |
1 |
NG-25 |
MAP3K7 (TAK1) |
58 |
861 |
2.33 |
2.63 |
2.62 |
-0.016 |
0.0094 |
0.0092 |
0.012 |
9.73e-06 |
4.23e-61 |
9.1e-01 |
1.6 |
a132 |
NRAS_mut |
155 |
1 |
1 |
AP-24534 |
ABL |
58 |
823 |
-0.669 |
0.395 |
0.56 |
0.166 |
0.1 |
0.099 |
0.15 |
2.74e-05 |
2.88e-37 |
9.06e-01 |
3.4 |
a239 |
NRAS_mut |
249 |
1 |
1 |
XL-184 |
VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL |
58 |
861 |
1.63 |
2.67 |
2.9 |
0.224 |
0.17 |
0.17 |
0.21 |
1.32e-04 |
1.24e-26 |
2.89e-01 |
9.1 |
a307 |
NRAS_mut |
308 |
1 |
1 |
XL-880 |
MET |
57 |
859 |
1.63 |
0.229 |
0.494 |
0.266 |
0.19 |
0.19 |
0.2 |
2.61e-04 |
8.18e-28 |
8.03e-01 |
14 |
a327 |
NRAS_mut |
1036 |
1 |
1 |
PLX4720 |
BRAF |
55 |
790 |
2.3 |
3.82 |
3.77 |
-0.0534 |
0.041 |
0.041 |
0.051 |
2.97e-04 |
6.44e-41 |
7.19e-01 |
15 |
