ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1526


Drug details and screening numbers

Drug Name: RDEA119 (rescreen)
Drug ID: 1526
Synonyms:
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 878
Screening concentration range(s): 0.01953125 to 5 uM


Statistically significant associations identified = 5
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a13
KRAS_mut
1526
1
1
RDEA119 (rescreen)
MAP2K1 (MEK1), MAP2K2 (MEK2)
116
759
1.61
1.86
0.673
-1.18
0.72 .
0.71 .
0.84 .
1.1e-10
9.33e-64
1.62e-01
0.00014
a94
NRAS_mut
1526
1
1
RDEA119 (rescreen)
MAP2K1 (MEK1), MAP2K2 (MEK2)
53
822
1.61
1.78
0.457
-1.32
0.8 .
0.8 .
0.76 .
8.08e-06
3.56e-62
1.68e-01
1.4
a104
BRAF_mut
1526
1
1
RDEA119 (rescreen)
MAP2K1 (MEK1), MAP2K2 (MEK2)
75
800
1.61
1.88
-0.236
-2.12
1.3 *
1.4 *
1.2 *
1.56e-05
4.38e-62
1.68e-01
2.5
a287
gain_cnaPANCAN344_(MYCN)
1526
1
1
RDEA119 (rescreen)
MAP2K1 (MEK1), MAP2K2 (MEK2)
37
838
1.61
1.65
2.75
1.09
0.65 .
0.65 .
0.95 .
2.12e-04
9.94e-62
1.69e-01
12
a474
CIC_mut
1526
1
1
RDEA119 (rescreen)
MAP2K1 (MEK1), MAP2K2 (MEK2)
14
861
1.61
1.69
2.5
0.818
0.49
0.48
0.61 .
6.41e-04
1.4e-61
1.7e-01
22


All-tests volcano plot