ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1014


Drug details and screening numbers

Drug Name: RDEA119
Drug ID: 1014
Synonyms: RDEA119
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 840
Screening concentration range(s): 0.01953125 to 5 uM


Statistically significant associations identified = 5

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a20	NRAS_mut	1014	1	1	RDEA119	MAP2K1 (MEK1), MAP2K2 (MEK2)	54	783	1.61	1.64	0.0136	-1.62	0.92 .	0.92 .	0.84 .	4.75e-10	1.37e-52	9.97e-02	0.00039
a38	KRAS_mut	1014	1	1	RDEA119	MAP2K1 (MEK1), MAP2K2 (MEK2)	106	731	1.61	1.69	0.454	-1.23	0.7 .	0.69 .	0.79 .	5.04e-08	5.44e-52	1.02e-01	0.022
a405	ASXL1_mut	1014	1	1	RDEA119	MAP2K1 (MEK1), MAP2K2 (MEK2)	15	822	1.61	1.56	-0.188	-1.75	0.97 .	0.97 .	0.99 .	4.83e-04	7.56e-51	1.05e-01	20
a442	loss_cnaPANCAN258	1014	1	1	RDEA119	MAP2K1 (MEK1), MAP2K2 (MEK2)	77	760	1.61	1.46	2.21	0.752	0.42	0.41	0.45	5.59e-04	7.88e-51	1.05e-01	21
a450	BRAF_mut	1014	1	1	RDEA119	MAP2K1 (MEK1), MAP2K2 (MEK2)	67	770	1.61	1.69	-0.295	-1.99	1.1 *	1.1 *	1.1 *	5.77e-04	7.95e-51	1.05e-01	21

All-tests volcano plot