ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1036


Drug details and screening numbers

Drug Name: PLX4720
Drug ID: 1036
Synonyms: Vemurafenib (derivative)
Brand name: Zelboraf (derivative)
Target: BRAF

Number of cell lines screened: 848
Screening concentration range(s): 0.0390625 to 10 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a5

BRAF_mut

1036

1

1

PLX4720

BRAF

69

776

2.3

4

1.77

-2.23

1.9 *

2.1 **

1.2 *

1.01e-22

1.18e-45

7.04e-01

3.3e-16

a327

NRAS_mut

1036

1

1

PLX4720

BRAF

55

790

2.3

3.82

3.77

-0.0534

0.041

0.041

0.051

2.97e-04

6.44e-41

7.19e-01

15

All-tests volcano plot