ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1372


Drug details and screening numbers

Drug Name: Trametinib
Drug ID: 1372
Synonyms: GSK1120212
Brand name: Mekinist
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 896
Screening concentration range(s): 0.00390625 to 1 uM


Statistically significant associations identified = 4
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a52
NRAS_mut
1372
1
1
Trametinib
MAP2K1 (MEK1), MAP2K2 (MEK2)
55
838
0
-0.92
-2.77
-1.85
0.75 .
0.76 .
0.65 .
5.36e-07
5.91e-63
2.16e-01
0.17
a74
KRAS_mut
1372
1
1
Trametinib
MAP2K1 (MEK1), MAP2K2 (MEK2)
112
781
0
-0.828
-2.47
-1.64
0.67 .
0.66 .
0.76 .
3.06e-06
1.03e-62
2.17e-01
0.68
a125
BRAF_mut
1372
1
1
Trametinib
MAP2K1 (MEK1), MAP2K2 (MEK2)
76
817
0
-0.792
-3.64
-2.85
1.2 *
1.2 *
1.1 *
2.21e-05
1.91e-62
2.18e-01
2.9
a472
CIC_mut
1372
1
1
Trametinib
MAP2K1 (MEK1), MAP2K2 (MEK2)
15
878
0
-1.06
0.599
1.66
0.66 .
0.66 .
0.98 .
6.23e-04
5.34e-62
2.2e-01
22


All-tests volcano plot