ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:10 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 249


Drug details and screening numbers

Drug Name: XL-184
Drug ID: 249
Synonyms: Cabozantinib
Brand name: Cometriq
Target: VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL

Number of cell lines screened: 922
Screening concentration range(s): 0.02 to 5.12 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a239	NRAS_mut	249	1	1	XL-184	VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL	58	861	1.63	2.67	2.9	0.224	0.17	0.17	0.21	1.32e-04	1.24e-26	2.89e-01	9.1
a240	U2AF1_mut	249	1	1	XL-184	VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL	5	914	1.63	2.7	0.172	-2.53	1.9 *	1.9 *	0.68 .	1.35e-04	1.24e-26	2.89e-01	9.3
a274	FLT3_mut	249	1	1	XL-184	VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL	11	908	1.63	2.7	1.37	-1.33	1 *	1 *	0.48	1.89e-04	1.31e-26	2.9e-01	11

All-tests volcano plot