ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:21 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: FLT3_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in FLT3

Number of cell lines positive for this feature: 11


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a14	FLT3_mut	277	1	1	ABT-869	VEGFR and PDGFR family	11	910	0.0237	2.3	0.585	-1.72	1.8 *	1.9 *	0.5 .	1.5e-10	1.19e-27	9.51e-01	0.00017
a40	FLT3_mut	254	1	1	AC220	FLT3	11	909	0.0237	2.15	0.534	-1.62	1.5 *	1.6 *	0.44	5.91e-08	2.62e-48	9.4e-01	0.024
a274	FLT3_mut	249	1	1	XL-184	VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL	11	908	1.63	2.7	1.37	-1.33	1 *	1 *	0.48	1.89e-04	1.31e-26	2.9e-01	11

All-tests volcano plot