ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual drug analysis: 254
Drug details and screening numbers
Drug Name: AC220
Drug ID: 254
Synonyms: Quizartinib, AC-220
Brand name:
Target: FLT3
Number of cell lines screened: 923
Screening concentration range(s): 0.004 to 1.024 uM
Statistically significant associations identified = 4
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a40 |
FLT3_mut |
254 |
1 |
1 |
AC220 |
FLT3 |
11 |
909 |
0.0237 |
2.15 |
0.534 |
-1.62 |
1.5 * |
1.6 * |
0.44 |
5.91e-08 |
2.62e-48 |
9.4e-01 |
0.024 |
a43 |
U2AF1_mut |
254 |
1 |
1 |
AC220 |
FLT3 |
5 |
915 |
0.0237 |
2.15 |
-0.515 |
-2.66 |
2.5 ** |
2.6 ** |
0.62 . |
8.26e-08 |
2.85e-48 |
9.4e-01 |
0.032 |
a308 |
BCR-ABL_mut |
254 |
1 |
1 |
AC220 |
FLT3 |
5 |
915 |
0.0237 |
2.13 |
1.97 |
-0.162 |
0.15 |
0.15 |
0.24 |
2.69e-04 |
2.17e-47 |
9.4e-01 |
14 |
a448 |
loss_cnaPANCAN169 |
254 |
1 |
1 |
AC220 |
FLT3 |
27 |
893 |
0.0237 |
2.16 |
1.29 |
-0.87 |
0.83 . |
0.87 . |
0.41 |
5.77e-04 |
2.61e-47 |
9.4e-01 |
21 |
All-tests volcano plot
