ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 155


Drug details and screening numbers

Drug Name: AP-24534
Drug ID: 155
Synonyms: KIN001-192
Brand name: Ponatinib
Target: ABL

Number of cell lines screened: 884
Screening concentration range(s): 0.002 to 0.512 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a36

BCR-ABL_mut

155

1

1

AP-24534

ABL

5

876

-0.669

0.437

-5.13

-5.57

3.5 **

3.5 **

1.9 *

4.73e-08

7.17e-38

9.05e-01

0.021

a132

NRAS_mut

155

1

1

AP-24534

ABL

58

823

-0.669

0.395

0.56

0.166

0.1

0.099

0.15

2.74e-05

2.88e-37

9.06e-01

3.4

All-tests volcano plot