ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1060


Drug details and screening numbers

Drug Name: PD-0325901
Drug ID: 1060
Synonyms: PD-0325901
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 841
Screening concentration range(s): 0.0009765625 to 0.25 uM and 0.0078125 to 2 uM


Statistically significant associations identified = 2

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a15	NRAS_mut	1060	1	1	PD-0325901	MAP2K1 (MEK1), MAP2K2 (MEK2)	54	784	-1.386, 0.693	-0.994	-2.57	-1.58	0.9 .	0.9 .	0.86 .	1.51e-10	2.24e-47	3.05e-02	0.00017
a29	KRAS_mut	1060	1	1	PD-0325901	MAP2K1 (MEK1), MAP2K2 (MEK2)	107	731	-1.386, 0.693	-0.937	-2.18	-1.24	0.71 .	0.7 .	0.77 .	5.99e-09	6.16e-47	3.13e-02	0.0034

All-tests volcano plot