ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 261


Drug details and screening numbers

Drug Name: TL-1-85
Drug ID: 261
Synonyms:
Brand name:
Target: MAP3K7 (TAK1)

Number of cell lines screened: 922
Screening concentration range(s): 0.04 to 10.24 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a9

BCR-ABL_mut

261

1

1

TL-1-85

MAP3K7 (TAK1)

5

914

2.33

3.21

-4

-7.21

4.6 **

4.6 **

7.2 **

1.44e-14

1.46e-78

5.64e-01

2.6e-08

a90

NRAS_mut

261

1

1

TL-1-85

MAP3K7 (TAK1)

58

861

2.33

3.18

3.03

-0.153

0.093

0.092

0.11

7.33e-06

2.09e-75

5.72e-01

1.3

All-tests volcano plot