ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1498


Drug details and screening numbers

Drug Name: AZD6244
Drug ID: 1498
Synonyms:
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 921
Screening concentration range(s): 0.015625 to 4 uM


Statistically significant associations identified = 5
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a22
KRAS_mut
1498
1
1
AZD6244
MAP2K1 (MEK1), MAP2K2 (MEK2)
121
797
1.39
1.8
0.627
-1.17
0.69 .
0.68 .
0.78 .
5.44e-10
1.34e-55
5.9e-02
0.00041
a46
BRAF_mut
1498
1
1
AZD6244
MAP2K1 (MEK1), MAP2K2 (MEK2)
79
839
1.39
1.84
-0.371
-2.21
1.4 *
1.4 *
1.1 *
1.57e-07
6.7e-55
6.06e-02
0.056
a54
NRAS_mut
1498
1
1
AZD6244
MAP2K1 (MEK1), MAP2K2 (MEK2)
57
861
1.39
1.73
0.364
-1.37
0.8 .
0.8 .
0.73 .
8.74e-07
1.08e-54
6.11e-02
0.27
a217
HRAS_mut
1498
1
1
AZD6244
MAP2K1 (MEK1), MAP2K2 (MEK2)
8
910
1.39
1.66
-0.426
-2.09
1.2 *
1.2 *
1.2 *
1.05e-04
4.07e-54
6.24e-02
7.9
a273
gain_cnaPANCAN344_(MYCN)
1498
1
1
AZD6244
MAP2K1 (MEK1), MAP2K2 (MEK2)
40
878
1.39
1.6
2.69
1.1
0.63 .
0.62 .
0.99 .
1.87e-04
4.76e-54
6.26e-02
11


All-tests volcano plot