ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:50 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: HRAS_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in HRAS

Number of cell lines positive for this feature: 8


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a147

HRAS_mut

94

1

1

TGX221

PI3Kbeta

3

397

2.3

3.84

1.68

-2.16

1.9 *

1.9 *

0.6 .

3.62e-05

8.96e-14

6.65e-01

4.1

a217

HRAS_mut

1498

1

1

AZD6244

MAP2K1 (MEK1), MAP2K2 (MEK2)

8

910

1.39

1.66

-0.426

-2.09

1.2 *

1.2 *

1.2 *

1.05e-04

4.07e-54

6.24e-02

7.9

All-tests volcano plot