ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1019


Drug details and screening numbers

Drug Name: Bosutinib
Drug ID: 1019
Synonyms: SKI-606
Brand name: Bosulif
Target: SRC, ABL, TEC

Number of cell lines screened: 851
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a69

BCR-ABL_mut

1019

1

1

Bosutinib

SRC, ABL, TEC

6

842

0.693

1.77

-1.56

-3.33

2.4 **

2.4 **

19 **

2.82e-06

5.4e-28

1.1e-01

0.67

a408

ASXL1_mut

1019

1

1

Bosutinib

SRC, ABL, TEC

16

832

0.693

1.78

-0.0662

-1.85

1.3 *

1.3 *

2 **

4.9e-04

1.35e-27

1.12e-01

20

All-tests volcano plot