ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1029


Drug details and screening numbers

Drug Name: AMG-706
Drug ID: 1029
Synonyms: AMG-706
Brand name: Motesanib Diphosphate
Target: VEGFR, RET, c-KIT, PDGFR

Number of cell lines screened: 849
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a41	gain_cnaPANCAN192_(FIP1L1,PDGFRA)	1029	1	1	AMG-706	VEGFR, RET, c-KIT, PDGFR	14	832	0.693	2.7	1.27	-1.43	1.6 *	1.6 *	0.96 .	6.22e-08	1.08e-07	6.43e-01	0.025
a85	gain_cnaPANCAN191_(FIP1L1,PDGFRA)	1029	1	1	AMG-706	VEGFR, RET, c-KIT, PDGFR	13	833	0.693	2.7	1.4	-1.29	1.4 *	1.5 *	0.77 .	5.2e-06	1.44e-07	6.44e-01	1
a135	CDKN1B_mut	1029	1	1	AMG-706	VEGFR, RET, c-KIT, PDGFR	5	841	0.693	2.69	0.965	-1.72	1.9 *	2 *	0.43	2.9e-05	1.61e-07	6.45e-01	3.5

All-tests volcano plot