ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:22 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: CDKN1B_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in CDKN1B

Number of cell lines positive for this feature: 6


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a17	CDKN1B_mut	1009	1	1	ATRA	Retinoic acid and retinoid X receptor agonist	5	832	2.3	3.92	0.0304	-3.89	3 **	3.1 **	1.4 *	2.9e-10	3.35e-32	2.03e-01	0.00028
a71	CDKN1B_mut	277	1	1	ABT-869	VEGFR and PDGFR family	6	915	0.0237	2.3	0.101	-2.2	2.3 **	2.4 **	0.74 .	3e-06	6.14e-27	9.52e-01	0.68
a123	CDKN1B_mut	271	1	1	VNLG/124	HDAC, RAR	6	910	1.63	3.8	1.8	-2	2.1 **	2.1 **	0.92 .	2.13e-05	7.19e-67	2.23e-01	2.9
a135	CDKN1B_mut	1029	1	1	AMG-706	VEGFR, RET, c-KIT, PDGFR	5	841	0.693	2.69	0.965	-1.72	1.9 *	2 *	0.43	2.9e-05	1.61e-07	6.45e-01	3.5

All-tests volcano plot