ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:10
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1129


Drug details and screening numbers

Drug Name: PF-4708671
Drug ID: 1129
Synonyms:
Brand name:
Target: RPS6KB1 (p70S6KA)

Number of cell lines screened: 908
Screening concentration range(s): 0.0390625 to 10 uM


Statistically significant associations identified = 5
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a234
loss_cnaPANCAN261
1129
1
1
PF-4708671
RPS6KB1 (p70S6KA)
81
824
2.3
3.8
4.23
0.432
0.46
0.45
0.55 .
1.26e-04
6.28e-08
6.84e-02
8.8
a297
BRCA1_mut
1129
1
1
PF-4708671
RPS6KB1 (p70S6KA)
14
891
2.3
3.82
4.8
0.979
1 *
1 *
1.1 *
2.29e-04
6.52e-08
6.85e-02
13
a354
loss_cnaPANCAN259, loss_cnaPANCAN260
1129
1
1
PF-4708671
RPS6KB1 (p70S6KA)
82
823
2.3
3.8
4.2
0.399
0.43
0.42
0.5
3.56e-04
6.7e-08
6.87e-02
17
a479
loss_cnaPANCAN258
1129
1
1
PF-4708671
RPS6KB1 (p70S6KA)
91
814
2.3
3.8
4.17
0.371
0.4
0.39
0.45
6.56e-04
6.96e-08
6.88e-02
23
a488
loss_cnaPANCAN93
1129
1
1
PF-4708671
RPS6KB1 (p70S6KA)
105
800
2.3
3.79
4.19
0.402
0.43
0.42
0.54 .
6.92e-04
6.98e-08
6.89e-02
23


All-tests volcano plot