ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1264


Drug details and screening numbers

Drug Name: SGC0946
Drug ID: 1264
Synonyms:
Brand name:
Target: Q8TEK3 (DOT1L)

Number of cell lines screened: 910
Screening concentration range(s): 0.001953125 to 0.5 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a57

USP6_mut

1264

1

1

SGC0946

Q8TEK3 (DOT1L)

8

899

-0.693

1.74

0.775

-0.969

1.7 *

1.7 *

0.79 .

1.17e-06

3.81e-24

6.7e-03

0.34

a62

GNAS_mut

1264

1

1

SGC0946

Q8TEK3 (DOT1L)

3

904

-0.693

1.74

0.5

-1.24

2.2 **

2.2 **

0.73 .

2.16e-06

4.18e-24

6.73e-03

0.57

All-tests volcano plot