ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:31 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual Feature analysis: GNAS_mut
Feature details and cell panel numbers
Binary feature equal to 1 for samples harboring mutations in GNAS
Number of cell lines positive for this feature: 4
Statistically significant associations identified = 3
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a62 |
GNAS_mut |
1264 |
1 |
1 |
SGC0946 |
Q8TEK3 (DOT1L) |
3 |
904 |
-0.693 |
1.74 |
0.5 |
-1.24 |
2.2 ** |
2.2 ** |
0.73 . |
2.16e-06 |
4.18e-24 |
6.73e-03 |
0.57 |
a127 |
GNAS_mut |
193 |
1 |
1 |
GW-2580 |
CSF1R (cFMS) |
4 |
917 |
3 |
5.29 |
4.11 |
-1.18 |
1.6 * |
1.6 * |
1.1 * |
2.23e-05 |
1.93e-25 |
3.44e-01 |
2.9 |
a426 |
GNAS_mut |
206 |
1 |
1 |
Ruxolitinib |
JAK1, JAK2, TYK2 |
4 |
918 |
1.6563, 0.0237 |
3.99 |
2.91 |
-1.08 |
1.1 * |
1.1 * |
0.83 . |
5.22e-04 |
1.19e-49 |
8.86e-01 |
20 |
All-tests volcano plot
