ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual drug analysis: 206
Drug details and screening numbers
Drug Name: Ruxolitinib
Drug ID: 206
Synonyms: INCB-18424
Brand name: Jakafi
Target: JAK1, JAK2, TYK2
Number of cell lines screened: 925
Screening concentration range(s): 0.02046875 to 5.24 uM and 0.004 to 1.024 uM
Statistically significant associations identified = 3
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a51 |
gain_cnaPANCAN139 |
206 |
1 |
1 |
Ruxolitinib |
JAK1, JAK2, TYK2 |
18 |
904 |
1.6563, 0.0237 |
4 |
3.03 |
-0.968 |
1 * |
1.1 * |
0.42 |
4.78e-07 |
1.96e-50 |
8.85e-01 |
0.15 |
a80 |
HLA-B_mut |
206 |
1 |
1 |
Ruxolitinib |
JAK1, JAK2, TYK2 |
5 |
917 |
1.6563, 0.0237 |
3.99 |
2.05 |
-1.94 |
2.1 ** |
2.1 ** |
0.56 . |
4.15e-06 |
3.45e-50 |
8.85e-01 |
0.86 |
a426 |
GNAS_mut |
206 |
1 |
1 |
Ruxolitinib |
JAK1, JAK2, TYK2 |
4 |
918 |
1.6563, 0.0237 |
3.99 |
2.91 |
-1.08 |
1.1 * |
1.1 * |
0.83 . |
5.22e-04 |
1.19e-49 |
8.86e-01 |
20 |
All-tests volcano plot
