ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:11 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 182


Drug details and screening numbers

Drug Name: Obatoclax Mesylate
Drug ID: 182
Synonyms:
Brand name: GX15-070
Target: BCL2, BCL2L1, MCL1

Number of cell lines screened: 867
Screening concentration range(s): 0.0625 to 16 uM


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a280	DLG1_mut	182	1	1	Obatoclax Mesylate	BCL2, BCL2L1, MCL1	6	858	2.77	-0.92	1.52	2.44	1.4 *	1.4 *	0.65 .	2.01e-04	4.65e-14	2.95e-02	12
a358	BPTF_mut	182	1	1	Obatoclax Mesylate	BCL2, BCL2L1, MCL1	13	851	2.77	-0.922	0.366	1.29	0.75 .	0.75 .	0.51 .	3.63e-04	4.94e-14	2.96e-02	17
a410	CHEK2_mut	182	1	1	Obatoclax Mesylate	BCL2, BCL2L1, MCL1	5	859	2.77	-0.916	1.36	2.28	1.3 *	1.3 *	0.76 .	4.92e-04	5.09e-14	2.97e-02	20
a510	HGF_mut	182	1	1	Obatoclax Mesylate	BCL2, BCL2L1, MCL1	5	859	2.77	-0.918	1.68	2.59	1.5 *	1.5 *	0.92 .	7.55e-04	5.32e-14	2.97e-02	24

All-tests volcano plot