ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 30


Drug details and screening numbers

Drug Name: Sorafenib
Drug ID: 30
Synonyms: BAY-43-9006
Brand name: Nexavar
Target: PDGFRA, PDGFRB, KDR, KIT, FLT3

Number of cell lines screened: 404
Screening concentration range(s): 0.015625 to 4 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a72	U2AF1_mut	30	1	1	Sorafenib	PDGFRA, PDGFRB, KDR, KIT, FLT3	3	400	1.39	2.06	-1.53	-3.6	2.8 **	2.8 **	1 *	3.04e-06	1.99e-04	1.15e-02	0.68
a428	loss_cnaPANCAN168	30	1	1	Sorafenib	PDGFRA, PDGFRB, KDR, KIT, FLT3	10	393	1.39	2.07	0.725	-1.34	1 *	1.1 *	0.53 .	5.23e-04	3.07e-04	1.26e-02	20
a496	loss_cnaPANCAN169	30	1	1	Sorafenib	PDGFRA, PDGFRB, KDR, KIT, FLT3	13	390	1.39	2.08	0.821	-1.26	0.96 .	1 *	0.49	7.05e-04	3.14e-04	1.27e-02	23

All-tests volcano plot