ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 312


Drug details and screening numbers

Drug Name: AV-951
Drug ID: 312
Synonyms: Tivozanib
Brand name:
Target: VEGFR

Number of cell lines screened: 922
Screening concentration range(s): 5e-04 to 0.128 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a87

BCR-ABL_mut

312

1

1

AV-951

VEGFR

5

914

-2.06

0.296

-2.15

-2.45

3.2 **

3.2 **

2.1 **

6.23e-06

4.03e-52

9.64e-01

1.2

a429

loss_cnaPANCAN114_(CIITA)

312

1

1

AV-951

VEGFR

9

910

-2.06

0.292

-0.672

-0.965

1.2 *

1.3 *

0.48

5.24e-04

1.3e-51

9.64e-01

20

All-tests volcano plot