ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 326


Drug details and screening numbers

Drug Name: GSK690693
Drug ID: 326
Synonyms:
Brand name:
Target: AKT

Number of cell lines screened: 922
Screening concentration range(s): 0.04 to 10.24 uM


Statistically significant associations identified = 5

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a32	PTEN_mut	326	1	1	GSK690693	AKT	89	830	2.33	3.66	2.59	-1.08	0.62 .	0.63 .	0.53 .	1.37e-08	7.63e-51	7.81e-02	0.0071
a101	CNOT1_mut	326	1	1	GSK690693	AKT	7	912	2.33	3.58	0.709	-2.87	1.6 *	1.6 *	1.4 *	1.32e-05	4.66e-50	8.03e-02	2.1
a102	EWSR1-FLI1_mut	326	1	1	GSK690693	AKT	17	902	2.33	3.6	1.66	-1.94	1.1 *	1.1 *	0.95 .	1.33e-05	4.67e-50	8.03e-02	2.1
a163	PIK3CA_mut	326	1	1	GSK690693	AKT	88	831	2.33	3.62	2.96	-0.664	0.38	0.38	0.38	5.13e-05	6.62e-50	8.08e-02	5.2
a418	TBX3_mut	326	1	1	GSK690693	AKT	4	915	2.33	3.57	1.35	-2.22	1.3 *	1.3 *	0.7 .	5.13e-04	1.19e-49	8.15e-02	20

All-tests volcano plot