| Camptothecin |
Camptothecine, (+)-Camptothecin |
TOP1 |
DNA replication |
24360 |
GDSC2 |
808 |
SANGER |
| DMOG |
Dimethyloxalylglcine |
HIF-PH |
Metabolism |
560326 |
GDSC1 |
883 |
MGH |
| Doxorubicin |
Doxil, Rubex, Adriamycin, Adriablastin, Doxorubicine |
Anthracycline |
DNA replication |
31703 |
GDSC1 |
877 |
MGH |
| Doxorubicin |
|
Anthracycline |
DNA replication |
|
GDSC1 |
934 |
SANGER |
| Epirubicin |
Ellence, Farmorubicin, IMI-28 |
Anthracycline |
DNA replication |
41867 |
GDSC2 |
752 |
SANGER |
| Epothilone B |
Patupilone, EpoB, EPO906, GNF-PF-193 |
Microtubule stabiliser |
Mitosis |
448013 |
GDSC1 |
875 |
MGH |
| Leflunomide |
Sulol, SU-101, HWA-486, Arava |
Pyrimidine synthesis inhibitor |
DNA replication |
3899 |
GDSC2 |
728 |
SANGER |
| Methotrexate |
Abitrexate, Amethopterin, Rheumatrex, Trexall, Folex |
Antimetabolite |
DNA replication |
126941 |
GDSC1 |
947 |
SANGER |
| Midostaurin |
PKC412, benzoylstaurosporine, CGP-41251 |
PKC, PPK, FLT1, c-FGR, others |
Other |
several |
GDSC1 |
888 |
MGH |
| Parthenolide |
|
HDAC1 |
Chromatin histone acetylation |
7251185 |
GDSC1 |
401 |
MGH |
| Pyrimethamine |
Daraprim, Chloridine |
Dihydrofolate reductase (DHFR) |
Other |
4993 |
GDSC1 |
399 |
MGH |
| SN-38 |
7-Ethyl-10-Hydroxy-Camptothecin, SN 38 |
TOP1 |
DNA replication |
104842 |
GDSC1 |
952 |
SANGER |
| THZ-2-102-1 |
|
CDK7 |
Cell cycle |
none |
GDSC1 |
896 |
MGH |
| THZ-2-49 |
|
CDK9 |
Cell cycle |
none |
GDSC1 |
905 |
MGH |
| Thapsigargin |
Octanoic acid |
SERCA |
Other |
446378 |
GDSC1 |
858 |
MGH |
| Tozasertib |
MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 |
AURKA, AURKB, AURKC, others |
Mitosis |
5494449 |
GDSC1 |
394 |
MGH |
| Tozasertib |
MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 |
AURKA, AURKB, AURKC, others |
Mitosis |
5494449 |
GDSC2 |
49 |
SANGER |
| UNC0638 |
UNC-0638, UNC 0683 |
G9a and GLP methyltransferases |
Chromatin histone methylation |
46224516 |
GDSC1 |
913 |
MGH |
| UNC0638 |
UNC-0638, UNC 0683 |
G9a and GLP methyltransferases |
Chromatin histone methylation |
46224516 |
GDSC1 |
927 |
SANGER |
| WZ3105 |
|
SRC, ROCK2, NTRK2, FLT3, IRAK1, others |
Other |
none |
GDSC1 |
920 |
MGH |
| XMD14-99 |
|
ALK, CDK7, LTK, others |
Other, kinases |
none |
GDSC1 |
920 |
MGH |
| Zibotentan |
ZD4054, ZD-4054 |
Endothelin-1 receptor (EDNRA) |
Other |
9910224 |
GDSC1 |
918 |
MGH |
