5-azacytidine |
|
DNA methyltransferases |
Other |
|
GDSC2 |
740 |
SANGER |
BDILV000379a |
4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-4,5-dihydro-1H-imidazol-5-yl)benzonitrile |
BAZ2A, BAZ2B |
Chromatin histone acetylation |
|
GDSC2 |
717 |
SANGER |
BDOCA000347a |
4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide |
BRPF1, BRPF2, BRPF3 |
Chromatin histone acetylation |
|
GDSC2 |
717 |
SANGER |
Bromosporine |
ethyl N-[6-(3-methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate |
CECR2, BRD2, BRD4, BRD9 |
Chromatin other |
|
GDSC2 |
716 |
SANGER |
Camptothecin |
Camptothecine, (+)-Camptothecin |
TOP1 |
DNA replication |
24360 |
GDSC2 |
968 |
SANGER |
DMOG |
Dimethyloxalylglcine |
HIF-PH |
Metabolism |
560326 |
GDSC1 |
876 |
MGH |
Doxorubicin |
Doxil, Rubex, Adriamycin, Adriablastin, Doxorubicine |
Anthracycline |
DNA replication |
31703 |
GDSC1 |
870 |
MGH |
Doxorubicin |
|
Anthracycline |
DNA replication |
|
GDSC1 |
922 |
SANGER |
Epirubicin |
Ellence, Farmorubicin, IMI-28 |
Anthracycline |
DNA replication |
41867 |
GDSC2 |
958 |
SANGER |
Epothilone B |
Patupilone, EpoB, EPO906, GNF-PF-193 |
Microtubule stabiliser |
Mitosis |
448013 |
GDSC1 |
868 |
MGH |
FY026 |
[(para-cymene)osmium(N,N-dimethylphenlyazopyridine)(iodide)]hexafluorophophate |
|
Unclassified |
|
GDSC1 |
915 |
SANGER |
GSK2801 |
1-(7-(2-methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone |
|
Chromatin other |
|
GDSC2 |
717 |
SANGER |
Leflunomide |
Sulol, SU-101, HWA-486, Arava |
Pyrimidine synthesis inhibitor |
DNA replication |
3899 |
GDSC2 |
894 |
SANGER |
Methotrexate |
Abitrexate, Amethopterin, Rheumatrex, Trexall, Folex |
Antimetabolite |
DNA replication |
126941 |
GDSC1 |
933 |
SANGER |
Methotrexate |
Abitrexate, Amethopterin, Rheumatrex, Trexall, Folex |
Antimetabolite |
DNA replication |
126941 |
GDSC2 |
881 |
SANGER |
Midostaurin |
PKC412, benzoylstaurosporine, CGP-41251 |
PKC, PPK, FLT1, c-FGR, others |
Other |
several |
GDSC1 |
881 |
MGH |
N23918-95-7 |
|
JMJ histone demethylase |
Chromatin histone methylation |
|
GDSC1 |
913 |
SANGER |
N24798-49-A1 |
|
JMJ histone demethylase |
Chromatin histone methylation |
|
GDSC1 |
908 |
SANGER |
Parthenolide |
|
HDAC1 |
Chromatin histone acetylation |
7251185 |
GDSC1 |
400 |
MGH |
Pyrimethamine |
Daraprim, Chloridine |
Dihydrofolate reductase (DHFR) |
Other |
4993 |
GDSC1 |
398 |
MGH |
SGC-CBP30 |
8-(3-chloro-4-methoxy-phenethyl)-4-(3,5-dimethyl-isoxazol-4-yl)-9-(2-(morpholin-4-yl)-propyl)-7,9-diaza-bicyclo[4.3.0]nona-1(6),2,4,7-tetraene |
EP300, CBP |
Chromatin histone acetylation |
|
GDSC2 |
716 |
SANGER |
SN-38 |
7-Ethyl-10-Hydroxy-Camptothecin, SN 38 |
TOP1 |
DNA replication |
104842 |
GDSC1 |
938 |
SANGER |
SN-38 |
7-Ethyl-10-Hydroxy-Camptothecin, SN 38 |
TOP1 |
DNA replication |
104842 |
GDSC2 |
958 |
SANGER |
Schweinfurthin A |
|
|
Unclassified |
|
GDSC2 |
716 |
SANGER |
THR-101 |
WIMM synthesis |
Mutant RAS |
PI3K/MTOR signaling |
None |
GDSC2 |
731 |
SANGER |
THR-102 |
WIMM synthesis |
Mutant RAS |
PI3K/MTOR signaling |
None |
GDSC2 |
731 |
SANGER |
THR-103 |
WIMM synthesis |
Mutant RAS |
PI3K/MTOR signaling |
None |
GDSC2 |
731 |
SANGER |
THZ-1-87 |
|
BTK, BMX |
Other, kinases |
|
GDSC1 |
99 |
SANGER |
THZ-2-102-1 |
|
CDK7 |
Cell cycle |
none |
GDSC1 |
890 |
MGH |
THZ-2-49 |
|
CDK9 |
Cell cycle |
none |
GDSC1 |
899 |
MGH |
THZ-2-98-01 |
|
IRAK1 |
Unclassified |
|
GDSC1 |
99 |
SANGER |
Thapsigargin |
Octanoic acid |
SERCA |
Other |
446378 |
GDSC1 |
852 |
MGH |
Tozasertib |
MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 |
AURKA, AURKB, AURKC, others |
Mitosis |
5494449 |
GDSC1 |
392 |
MGH |
Tozasertib |
MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 |
AURKA, AURKB, AURKC, others |
Mitosis |
5494449 |
GDSC2 |
268 |
SANGER |
UNC0638 |
UNC-0638, UNC 0683 |
G9a and GLP methyltransferases |
Chromatin histone methylation |
46224516 |
GDSC1 |
907 |
MGH |
UNC0638 |
UNC-0638, UNC 0683 |
G9a and GLP methyltransferases |
Chromatin histone methylation |
46224516 |
GDSC1 |
914 |
SANGER |
WZ3105 |
|
SRC, ROCK2, NTRK2, FLT3, IRAK1, others |
Other |
none |
GDSC1 |
914 |
MGH |
XMD14-99 |
|
ALK, CDK7, LTK, others |
Other, kinases |
none |
GDSC1 |
914 |
MGH |
ZL049 |
[(diphenyltetramethylcyclopentadienyl)iridium(III)(2-phenylpyridine)(chloride)] |
|
Unclassified |
|
GDSC1 |
913 |
SANGER |
Zibotentan |
ZD4054, ZD-4054 |
Endothelin-1 receptor (EDNRA) |
Other |
9910224 |
GDSC1 |
912 |
MGH |
glutathione |
G6013, sigma |
anti-oxidant proteins |
Other |
|
GDSC2 |
732 |
SANGER |