ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1013


Drug details and screening numbers

Drug Name: Nilotinib
Drug ID: 1013
Synonyms:
Brand name: Tasigna
Target: ABL

Number of cell lines screened: 803
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a3	BCR-ABL_mut	1013	1	1	Nilotinib	ABL	6	794	0.693	2.71	-5.32	-8.03	6.9 **	6.9 **	14 **	2.26e-42	3.51e-47	1.61e-01	1.2e-35
a25	ASXL1_mut	1013	1	1	Nilotinib	ABL	16	784	0.693	2.71	-0.27	-2.98	2.3 **	2.4 **	0.92 .	1.14e-09	2.27e-38	2.03e-01	0.00075
a436	MLH3_mut	1013	1	1	Nilotinib	ABL	6	794	0.693	2.66	1.02	-1.64	1.2 *	1.2 *	0.6 .	5.36e-04	5.12e-37	2.11e-01	20
a505	loss_cnaPANCAN72	1013	1	1	Nilotinib	ABL	5	795	0.693	2.66	1.06	-1.6	1.2 *	1.2 *	1.6 *	7.37e-04	5.5e-37	2.11e-01	24

All-tests volcano plot