ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:11 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1248


Drug details and screening numbers

Drug Name: FK866
Drug ID: 1248
Synonyms: APO866
Brand name:
Target: NAMPT

Number of cell lines screened: 901
Screening concentration range(s): 0.00390625 to 1 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a250

EWSR1-FLI1_mut

1248

1

1

FK866

NAMPT

17

881

0

-2.51

-5.69

-3.19

1 *

1 *

1.5 *

1.55e-04

6.28e-40

9.71e-04

10

a521

loss_cnaPANCAN369

1248

1

1

FK866

NAMPT

115

783

0

-2.74

-1.41

1.33

0.44

0.44

0.44

7.78e-04

8.94e-40

9.91e-04

25

All-tests volcano plot