ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 252


Drug details and screening numbers

Drug Name: WZ3105
Drug ID: 252
Synonyms:
Brand name:
Target: CLK2, CNSK1E, FLT3, ULK1

Number of cell lines screened: 924
Screening concentration range(s): 0.005 to 1.28 uM and 0.04 to 10.24 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a129	EWSR1-FLI1_mut	252	1	1	WZ3105	CLK2, CNSK1E, FLT3, ULK1	17	904	0.247, 2.326	0.155	-1.54	-1.7	1 *	1 *	1.3 *	2.39e-05	4.8e-58	9.63e-01	3.1
a372	loss_cnaPANCAN326_(SOX9)	252	1	1	WZ3105	CLK2, CNSK1E, FLT3, ULK1	10	911	0.247, 2.326	0.105	1.86	1.75	1 *	1 *	1 *	3.83e-04	1.06e-57	9.63e-01	17
a528	loss_cnaPANCAN368	252	1	1	WZ3105	CLK2, CNSK1E, FLT3, ULK1	122	799	0.247, 2.326	0.0209	0.8	0.779	0.47	0.47	0.47	7.99e-04	1.3e-57	9.63e-01	25

All-tests volcano plot