ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 263


Drug details and screening numbers

Drug Name: FR-180204
Drug ID: 263
Synonyms:
Brand name:
Target: ERK

Number of cell lines screened: 922
Screening concentration range(s): 0.078125 to 20 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a59

EWSR1-FLI1_mut

263

1

1

FR-180204

ERK

17

902

3

4.92

3.99

-0.925

1.1 *

1.1 *

1.9 *

1.37e-06

5.39e-37

7.83e-01

0.38

a89

BRAF_mut

263

1

1

FR-180204

ERK

78

841

3

4.93

4.63

-0.302

0.34

0.35

0.33

7.29e-06

7.62e-37

7.83e-01

1.3

All-tests volcano plot