ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 272


Drug details and screening numbers

Drug Name: AR-42
Drug ID: 272
Synonyms: HDAC-42
Brand name:
Target: HDAC

Number of cell lines screened: 913
Screening concentration range(s): 0.02 to 5.12 uM


Statistically significant associations identified = 5

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a120	EWSR1-FLI1_mut	272	1	1	AR-42	HDAC	17	893	1.63	-0.251	-1.3	-1.05	0.61 .	0.6 .	1 .	2.03e-05	1.99e-33	6.34e-01	2.8
a187	TBX3_mut	272	1	1	AR-42	HDAC	4	906	1.63	-0.285	2.96	3.25	1.9 *	1.9 *	1.1 *	6.82e-05	2.51e-33	6.34e-01	6
a268	CLSPN_mut	272	1	1	AR-42	HDAC	11	899	1.63	-0.293	1.6	1.89	1.1 *	1.1 *	0.79 .	1.79e-04	3.02e-33	6.34e-01	11
a342	DICER1_mut	272	1	1	AR-42	HDAC	6	904	1.63	-0.285	1.86	2.15	1.3 *	1.3 *	0.85 .	3.34e-04	3.4e-33	6.35e-01	16
a513	ABCB1_mut	272	1	1	AR-42	HDAC	16	894	1.63	-0.293	0.98	1.27	0.74 .	0.75 .	0.51 .	7.63e-04	3.96e-33	6.35e-01	25

All-tests volcano plot