ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 38


Drug details and screening numbers

Drug Name: AZD-0530
Drug ID: 38
Synonyms: Saracatinib,KIN001-045
Brand name:
Target: SRC, ABL1

Number of cell lines screened: 409
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a44

BCR-ABL_mut

38

1

1

AZD-0530

SRC, ABL1

5

403

0.693

2.2

-0.794

-2.99

2.6 **

2.6 **

2.4 **

1.27e-07

7.54e-06

6.34e-01

0.048

a241

NOTCH1_mut

38

1

1

AZD-0530

SRC, ABL1

10

398

0.693

2.21

0.491

-1.71

1.5 *

1.5 *

0.94 .

1.39e-04

1.57e-05

6.4e-01

9.6

All-tests volcano plot